In Season 19, South Park introduced a new character, PC Principle, whose mission is to enforce all things Politically Correct.
In the previously mentioned episode “Chef Goes Nanners”, South Park character Uncle Jimbo asks what’ll come next if and when South Park decides to change its flag, “What about the baseball team, the Cleveland Indians, huh?
Three years before the Carnival “poop cruise” disaster of 2013, South Park dropped an offhanded quip in Season 14, episode 14 (“Creme Fraiche”).
In 2014, South Park aired an episode titled “Gluten Free Ebola”, where town residents begin to experience violent gluten-related deaths.