The character was originally going to appear in a scene in Space Jam: A New Legacy with Jane the Virgin actor Greice Santo, the setup meant to spoof Casablanca, but apparently the moment was an inclusion by original director Terence Nance, and it has since been removed by current director Malcolm D. Lee.
Being a skunk who pursues a romantic relationship with a cat despite being rebuffed thousands of times, Pepe Le Pew is not a character that is a character that comes across as pretty damn gross in the modern era, and according to Deadline it seems like Warner Bros. is making steps towards retiring him from the Looney Tunes canon.