For Spider-Man 3 they might have to update the character a little bit to be more 21st century, but the original motives of the villain would suit the blockbuster’s setup perfectly.
Sergei Kravinoff has been around pretty much since the beginning of Spider-Man’s existence, having been introduced in August 1964’s The Amazing Spider-Man #15.
Kraven The Hunter a.k.a.
It’s not entirely clear if he will be available to use in the Marvel Cinematic Universe because other stuff Sony is cooking up, but he is definitely a top choice.