Thanks to Jake Gyllenhaal’s performance and the big twist surrounding the character, he certainly ranks as one of the more memorable Spider-Man film villains, especially for that mid-credits shocker, where before dying, Quentin Beck framed Spider-Man for murder and revealed to the world that he was Peter Parker.
Mysterio has been antagonizing Spider-Man in the comics for over five decades, but Spider-Man: Far From Home marked his theatrical debut (apparently there were plans to feature him in Sam Raimi’s cancelled Spider-Man 4, though Bruce Campbell wouldn’t have played him).