The biggest singular diversion from what fans are used to is the introduction of a mask for Keaton’s Vulture.
The most immediately striking thing is that, unlike the classic version from the world of Marvel comics where Toomes wears a green, skin-tight suit with feather-style wings, this Vulture wingsuit in Spider-Man: Homecoming is more mechanical.
The character or suit presumably has some link to the Air Force judging by the suit’s design, suggesting this could even be an unused military prototype.
It’s also considerably larger, with a much larger wingspan than even the more stylized comic book iterations.