This will be rather similar to comic Peter Parker’s actions post-Secret Wars in the 1980s that introduced the Venom symbiote, an arc that could provide vague inspiration for the sequel.
Spider-Man’s got a very bright future in the MCU for the rest of the current decade, with a mixture of classic adventures in New York and cosmic travels with the Avengers.
Infinity War, the Russo brothers’ epic culmination of the entire franchise thus far is shooting back-to-back with Avengers 4, but after their names were changed from Part 1 and Part 2 the distinction between the duology has been unclear.
It also sheds a little light on Spidey’s future; Homecoming 2 comes out on July 5, 2019, mere months after Avengers 4, meaning the solo outing will likely deal with the fallout of the two-movie event.