Mahershala Ali won Best Supporting Actor for Green Book, while Regina King won Best Supporting Actress for her performance in If Beale Street Could Talk.
The film also won Best Original Screenplay and Best Supporting Actor for Ali, who won the same award in 2017 for Moonlight.
Elsewhere, The Favourite star Olivia Colman won Best Actress shortly after Rami Malek took home Best Actor for his portrayal of Freddie Mercury in Queen biopic Bohemian Rhapsody.
Spike Lee predicted the fallout from Green Book’s Best Picture Oscar win on the red carpet ahead of the ceremony.