Still, the boys would be dead (permanently, anyway) if they didn’t have help from Castiel (Misha Collins), Bobby (Jim Beaver) and a host of other friends they’ve made along the way.
Supernatural has always found a way to isolate Sam (Jared Padalecki) and Dean Winchester (Jensen Ackles).
Whether it’s killing off both of their parents or removing key characters from their lives, the brothers Winchester have had to rely on each other more than most.