The film has now earned $388.9 million in North America and $742.6 million overseas, for a worldwide total of $1.131 billion.
That Jonathan Liebesman-directed film went on to reach $191.2 million domestically and $302.1 million internationally, for a worldwide total of $493.3 million.
The debut of Teenage Mutant Ninja Turtles: Out of the Shadows marks a big drop from the $65.6 million the first film earned its first weekend in 2014.
Teenage Mutant Ninja Turtles 2, which received an A- CinemaScore from audiences, also grossed $34 million internationally this weekend for a global weekend total of $69.3 million.