Ellen Pompeo continues to lead the cast as Meredith Grey in a show that’s launched actors’ careers and whose guest stars are a Who’s Who of Hollywood A-listers.
We’ll try to keep it free of major spoilers, in case you’re a little late to the OR.
So how would one even begin to pick the ten best episodes from a series that’s attacked all of our emotions from every possible angle for nearly two decades?
We gathered Grey’s Anatomy’s most-talked-about moments, the biggest disasters, the most quotable lines and the rip-your-heart-out romances that allowed these talented actors to surgically insert themselves into our hearts.