Sadly, since Harold Ramis passed away in 2014, we can never see a complete Ghostbusters crossover unfold on the big screen.
The announcement indicates that Ghostbusters 101 will be a limited series, but depending on its sales and receptions, it could lay the groundwork for future crossovers between the two teams.
Fortunately, comic books have proved to be an excellent medium with all kinds of unusual crossovers, ranging from Green Lantern and Planet of the Apes to Star Trek: The Next Generation and Aliens.
Although this marks the first instance of the main two Ghostbusters teams working together, it won’t be the first time the original Ghostbusters have crossed over with another property in comics, as they’ve previously shared page space with The X-Files and the Teenage Mutant Ninja Turtles.