The current showrunner on The Big Bang Theory, Steve Molaro, would also be involved.
None of the other main characters from The Big Bang Theory universe would be involved in this prequel, as it would reportedly follow Sheldon in his teenage years or even younger.
The comedy is being described as a family comedy that would be Malcolm In The Middle-ish, except with a genius as the main kid in the story.
Along with the obvious differences, it looks as if a potential comedy spinoff would be a single camera endeavor rather than a multi-camera comedy.