The interesting thing is that according to the sources of LRM who broke this news, the opening of Avengers: Infinity War will actually be quite faithful to the opening of the Marvel comic with the other title.
The comic begins with Thanos the Mad Titan, who we have seen here and there since the closing credits of the original Avengers, attempting to woo the personification of Death.
At the beginning of the book, Thanos already has all of the Infinity Stones.
We’re guessing there might be one change to how this works in the comics.