Following the mini-apocalypse that left their small town flattened out and all its inhabitants dead in Preacher season 1, Jesse, Cassidy, and Tulip embark on a mission to locate the AWOL God.
In hindsight, Jesse, Cassidy and Tulip are both the hunters and the hunted in this situation.
By the end of the premiere, Jesse found himself face-to-face with the Saint with the latter aiming a gun at him.
Instead of the bullet reaching Jesse, it hits the truck driver causing the transport to pivot and hit Saint.