The Russo Brothers’ set of blockbusters had very high stakes, and plenty of characters perished during Thanos’ assault on the galaxy.
Spider-Man: Far From Home is the first movie that follows up the events of Endgame, and things do feel decidedly more serious after the events of that epic blockbuster.
Samuel L. Jackson also explicitly mentions that not all heroes make it out alive, in direct reference to the events of Avengers: Infinity War and Endgame.