Tom Cruise’s injury on the set of Mission: Impossible Fallout caused production to be switched around.
Everything turned out okay (it met its release date and was critically acclaimed), but there is certainly a question of the risk associated with these films.
At this point, it seems like the biggest barriers facing any more insane stunts for the next Mission: Impossible film are what is even possible, logistically and financially, and what can Tom Cruise and the production be insured for.