Nevertheless, there’s a good chance what happens in Avengers 4 won’t change the fact that Loki’s chronological end comes during the showdown with Thanos on the Asgardian refugee vessel, and Tom Hiddleston is pleased with the emotional resonance of that ending.
With all of that said, it’s impossible to ignore the fact that Loki could very well appear in the Marvel Cinematic Universe at least one more time.
There are rumors that Avengers 4 could potentially include time travel as a storytelling device, which means it remains possible for the surviving MCU heroes to bring the character back, or at least go back and see Loki again during an earlier point in his life.