Not only have Iron Man and Spider-Man been in all of Spider-Man’s previous MCU appearances, but the two characters have always performed alongside each other.
Working together like that you’re either going to become friends or drive each other crazy.
It had to be a little strange to be there and not see Downey.
Tom Holland actually reveals to Marvel at the premiere of Spider-Man: Far from Home that the pair spoke the evening before, so the friendship between the two actors is clearly still strong.