While Todd McFarlane and David Michelinie created the original version of Venom back in 1988, Mark Bagley created the Ultimate incarnation of the character with Brian Michael Bendis.
The Venom movie opted going with the alien origin, though interestingly enough, writers Jeff Pinker and Scott Rosenberg looked to the Ultimate version of Venom for inspiration on how to bring the antihero to life without Spider-Man being involved.
Rather than the Venom symbiote being an alien creature like in the 616 reality, the symbiote was an artificial “suit” that Peter Parker and Eddie Brock’s fathers designed that was intended to cure diseases and protect the user from all kinds of harm.