Even though Hope didn’t get to participate in Captain America: Civil War, the aftermath of that movie will play into the events of Ant-Man and the Wasp.
Regardless, Scott and Hope will need to put aside their differences and team up as Ant-Man and Wasp for a new mission, which will see them fighting Ghost.
At the start of Ant-Man and the Wasp, Scott and Hope have been estranged, and it’s entirely possible that Scott’s involvement in Civil War might be the reason that their relationship ended.
More importantly, this will be our first chance to see how skilled Hope is harnessing Pym particles and beating up bad guys out in the field.