The Sylvie Lushton Enchantress was introduced during the same “Dark Reign” period of Marvel as Lady Loki.
That’s because Lady Loki wasn’t created for this Disney+ show; she’s appeared in Thor comics — along with other Marvel series — for several years.
In Episode 2 of Loki, the variant of Loki who’s been meddling with the Marvel Cinematic Universe’s “sacred” timeline turns out to be a female version of Loki, played by Sophia Di Martino.
This Loki remained the primary version of the character in Marvel Comics for several years.