So with the ending of Alien: Covenant showing David getting cozy with the MUTHUR computer system that would later be revisited in the era of Alien, it’s a good bet there’s enough uncovered story that Scott’s remarks to EW hint at a lot of dots that are about to be connected.
The first synthetic in the legendary sci-fi series, Ash tried to help the Weyland-Yutani Corporation mine the Xenomorphs with the help / sacrifice of the Nostromo crew.
Some spoilers for Covenant can be found in this paragraph.
With the creation of the Xenomorphs, as well as the history of human encounters between Elizabeth Shaw and Ellen Ripley being finite story material, future Alien sequels could start to mine the connection between Fassbender’s David and Ian Holm’s Ash.