Green Goblin (played by the wonderful, but now-jaded on hero films Willem Dafoe) is his best friend’s dad, Doctor Octopus works for Oscorp and gives Peter a tour of his eventual doomsday machine, Sandman was the one who actually killed his Uncle Ben, and Eddie Brock just happens to be his co-worker at the Daily Bugle?
There’s a theory here that Peter drives people in life to take up arms against Spider-Man, but I’ll table that and just say it’s freaky he’s close to so many arch-enemies.
It’s not entirely rare for a hero to have a nemesis with some close ties, but it is truly remarkable that Tobey Maguire’s Peter Parker has a personal relationship with every major villain in the Sam Raimi movies.