As far as having Wade Wilson wind up with a guy on-screen, Ryan Reynolds is very open to the idea.
In the comics, Wade Wilson is rather flirtatious and goes both ways, as it were, having the distinction of being Marvel’s first pansexual hero.
Ryan Reynolds recently did a fairly lengthy and in-depth interview with Variety, and the subject of where Deadpool is going in the future came up.
At the moment, given what happened at the end of the first Deadpool, it looks like Wade Wilson will be carrying on happily with his girlfriend Vanessa (played by Morena Baccarin).