Dire wolves are hugely important animals on Game Of Thrones; the litter that belonged to the Stark children were introduced in the very first episode of the show and they are, of course, on the Stark sigil.
While most of the dire wolves (poor Lady) faced untimely deaths, one became one of the most beloved non-human characters on show. Jon Snow’s Ghost was by Jon’s side from Episode 1 of Season 1 right up until the Battle Of Winterfell in Season 8, where Ghost was part of an epic battle against the army of the dead, even losing an ear in the combat.