Either way, Emma and Madison will be among the main human characters getting the spotlight in Godzilla: King of the Monsters, and since the previous MonsterVerse movies, let alone most monsters movies, don’t highlighted mother/daughter relationships, this makes for a nice change of pace.
That’d be tragic, but in the MonsterVerse, tragedy comes in large supply.
That said, while both Millie Bobby Brown and Kyle Chandler are confirmed to appear in Godzilla vs. Kong, Vera Farmiga has not been announced as part of that cast.
It’s possible that Farmiga’s involvement either hasn’t been cemented or she’ll have a smaller role in the fourth MonsterVerse entry, but perhaps, just like how Ford Brody lost his father, Madison will lose her mother during King of the Monsters.