Losing Mary and Jack in quick succession surely won’t help.
Maybe Jared Padalecki will get his wish and the Winchesters will keep on fighting even after the final credits roll.
Still, they have each other, and they have Castiel.
Considering that they’re facing off against God/Chuck and a whole lot of creatures that they’d already killed/banished to Hell following the killer Season 14 cliffhanger, it would be hard to blame them if they despaired at least a little bit.