Justice League should have no problem making loads of money just like the other DCEU films, but just how much it makes will be dependent on the reviews.
Similarly to how Batman v Superman: Dawn of Justice was the true beginning of the universe, Justice League will help launch the DCEU in a new way.
The DCEU is riding high thanks to Wonder Woman, but Warner Bros. is reportedly waiting to see how Justice League performs before moving forward with their extensive slate.
The studio wants to see how Wonder Woman performs (so far so good on that front) and how Justice League turns out, before they barrel ahead with multiple more films every year.