The director, whose credits include Kung Fu Panda and The Little Prince, will shoot from a script he’s co-writing with Adam Kline.
The series ran irregularly from 1991 to 2005, with a total of 55 issues being released before it ended.
Warner Bros. has been trying to adapt Jeff Smith’s Eisner Award-winning comic Bone for years, but the studio has never managed to get the project off the ground.
Kline also commented on Bone, saying “As source material goes, Jeff’s epic is something of a unicorn: mythic, whimsical and pure in equal measure.”