The talk show host, who hosts Jimmy Kimmel Live!, instead quipped the choice was prompted by the First Lady hating her husband.
Her spokeswoman Stephanie Grisham said “scheduling and logistical issues” forced Ms Trump to change her plans but did not say what those issues were.
Melania Trump might have blamed her decision to pull out of a trip to the World Economic Forum in Switzerland on logistical problems but Jimmy Kimmel remains unconvinced.
Reminding viewers of the “saga”, Kimmel noted that “all of a sudden” Ms Trump opted not to join her husband in the eastern Alps region.