Unless the goal of Star Trek: Picard Season 2 is to retcon the J.J. Abrams films, I can’t imagine there’d be any lasting change that prevented Nero’s actions.
Of course, any change to that historic moment could potentially change the entirety of Star Trek as a whole.
All we know is that Q will return, which usually means some craziness for Picard and others.
The destruction of Romulus resulted in Nero’s arrival back in time via a time vortex, which created the Kelvin timeline.
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Q Returns For Star Trek: Picard Season 2 | First Contact Day | Paramount+