While none of the sequel’s antagonists have been announced yet, Marvel Studios president Kevin Feige said that they will not be anyone we’ve seen in any of the earlier, non-MCU Spider-Man movies.
But with Scorpion introduced in Spider-Man: Homecoming and a handful of other Spidey rogues who haven’t had the cinematic spotlight yet, Jon Watts and the creative team won’t have any problem finding at least one baddie to pit against the Web-Slinger.
No specific plot details for Spider-Man: Homecoming 2 have been revealed yet, but it will pick up immediately after Avengers 4 and explore Peter dealing with the aftermath of those events and the debut of a new super villain or two as he moves through his junior year of high school.