Evan Goldberg and Seth Rogen apparently mentioned Jesse to Franco early on in the production process, years before Preacher would premiere on AMC.
He may be too busy for a regular gig, but his connections to Evan Goldberg and Seth Rogen could possibly pull him in for a one-off appearance.
Of course, James Franco was never tied closely enough to Preacher that he would have been a serious candidate for the role of Jesse by the time production began.
Unlike the other comic-based series on the network, Preacher’s ratings have been mostly unimpressive throughout its first season.