While I tend to loath the retconning of villains into simply misunderstood heroes, like in Maleficent, Carmen Sandiego is simply a thief, not anything worse, so she could be a really fun protagonist.
The animated series, and I have to imagine the new movie, will be painting her as more of an anti-hero.
I imagine that Gina Rodriguez’s portrayal of the character will see Carmen Sandiego as something of a globetrotting adventurer like Lara Croft, with perhaps a little Indiana Jones and Nicolas Cage’s Ben Gates from National Treasure as well.
Carmen Sandiego was primarily a villain in previous depictions; she was an international thief who stole for the fun of it and was the leader of the V.I.L.E. criminal organization.