The series followed the adventures of secret agents Will Chase, played by Scott Foley (Scandal), and Frankie Trowbridge, played by Cohan, as they lead an inter-agency team of flawed, funny and heroic spies who periodically save the world.
The studio is Warner Bros. Television and Atencio directed the pilot, with Foley also producing.
Whiskey Cavalier also stars Ana Ortiz (Ugly Betty) as Susan Sampson, Tyler James Williams (Dear White People) as Edgar Standish and Vir Das (Son of Abish) as Jai Datta.
Executive producer Bill Lawrence took to Twitter on Sunday to confirm the bad news for fans of the series.