Beginning in earnest during the spring of 2008, Secret Invasion basically jumpstarted when the Skrull homeworld was destroyed during the 2007 Marvel Cosmic event Annihilation.
Much like every other Marvel Comics arc that has made its way to the big screen, any adaptation wouldn’t have to follow the source material beat-for-beat, but there is definitely a core concept in there that could make for excellent cinema.
The shapeshifting aliens made a plan to colonize Earth as a replacement, and their method for takeover was replacing key individuals with Skrulls in disguise.